Volterra, A
In terms of specific regulatory effects, the protective role of mitophagy is mainly reflected in a state of moderate activation: when cells are subjected to mild stress and mitochondria undergo local damage, mitophagy can specifically recognize and clear damaged, depolarized mitochondria, effectively reducing the abnormal release of ROS and the cytoplasmic leakage of mtDNA
At day 90, 5058% of patients in the DFO group have favorable outcomes, much higher than those in the placebo group (31%), suggesting that iron chelating therapy reduces systemic iron overload and may provide long-term benefits for patients with acute stroke
One-way or Two-way analysis of variance (ANOVA) and Bonferroni post hoc analyses were used in analyses with multiple experimental groups
In SURMOUNT-1, the most common adverse events at the 15 mg dose included nausea (31%), diarrhea (23%), constipation (11%), and vomiting (12%)